Fundraising
Once again, the Leukemia and Lymphoma Society will benefit from the funds raised during Creative Escape. Last year, our money went directly to Dr. Laurence Hurley in Tucson, Arizona. His research into lymphoma is really seeing results! It is so exciting to know our contributions will be making a difference to people with blood cancers. Save your pennies… there will be plenty to bid on this year.
Lymphoma Drug Discovery Work in the Hurley Lab at the University of Arizona
Research and Clinical Objective of the Lab
The overall objective of the Hurley lab is to bring to bear new therapies for cancers that are difficult to treat because either there are no existing drugs available or the cancers have become resistant to the already available effective drugs. Many lymphomas fall into both categories.
Approach
We have identified a new class of cancer-selective targets that are associated with the switch mechanism that turns cancer genes on and off. For lymphoma we have identified two specific cancer gene targets, c-Myc and Bcl-2. c-Myc is a critical cancer gene in Burkitt’s (90% of cases), diffuse large B-cell (10–25% of cases), transformed follicular (70% of cases), and mantle cell (up to 100% of cases) lymphomas, and Bcl-2 is commonly over expressed in lymphomas that have become resistant to chemotherapy. We are in the late stages of identifying new drug molecules to enter clinical trials for the treatment of lymphoma patients whose tumors are either insensitive to existing agents or have become resistant to previously successful treatment. Our plans call for bringing our first lymphoma drug into the clinic in the next one or two years. Because these drugs belong to the newer molecular-targeted types of cancer treatments, we do not expect to see the same toxicities associated with traditional chemotherapy.
Recent Track Record of the Hurley Lab
During the last eight years, our lab has been instrumental in bringing two cancer drugs from “bench to bedside” (from the lab to patients in clinical trials). In both cases, the compounds we identified in the lab were either taken directly into the clinic (MP470) or slightly modified (Quarfloxin) before being given to patients.
Class Supply List
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